Q-VD-OPh hydrate
- Product Name
- Q-VD-OPh hydrate
- CAS No.
- 1135695-98-5
- Chemical Name
- Q-VD-OPh hydrate
- Synonyms
- CS-2734;Q-VD-OPh hydrate;Q-VD-OPh (QVD-OPH;Quinoline-Val-Asp-Difluorophenoxymethylketone);QVD-OPH;QUINOLINE-VAL-ASP-DIFLUOROPHENOXYMETHYLKETONE;QVD-OPH,QVDOPH,inhibit,Caspase,Human immunodeficiency virus,Inhibitor,HIV,Q VD OPH;(3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid;Pentanoic acid, 5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-, (3S)-;(3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid hydrate
- CBNumber
- CB42652283
- Molecular Formula
- C26H25F2N3O6
- Formula Weight
- 513.49
- MOL File
- 1135695-98-5.mol
Q-VD-OPh hydrate Property
- Boiling point:
- 808.9±65.0 °C(Predicted)
- Density
- 1.346±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- -20°C
- solubility
- DMSO: ≥14mg/mL
- pka
- 3.92±0.19(Predicted)
- form
- powder
- color
- white to light brown
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChIKey
- OOBJCYKITXPCNS-REWPJTCUSA-N
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0063
- Product name
- Q-VD-OPh hydrate
- Purity
- ≥95% (HPLC)
- Packaging
- 1mg
- Price
- $258
- Updated
- 2024/03/01
- Product number
- SML0063
- Product name
- Q-VD-OPh hydrate
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $1030
- Updated
- 2024/03/01
- Product number
- 15260
- Product name
- Q-VD-OPH
- Purity
- ≥95% (mixture of tautomers)
- Packaging
- 1mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 15260
- Product name
- Q-VD-OPH
- Purity
- ≥95% (mixture of tautomers)
- Packaging
- 5mg
- Price
- $423
- Updated
- 2024/03/01
- Product number
- D446120
- Product name
- (3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoicAcid
- Packaging
- 25mg
- Price
- $1260
- Updated
- 2021/12/16
Q-VD-OPh hydrate Chemical Properties,Usage,Production
Description
Q-VD-OPH is a broad-spectrum caspase inhibitor, blocking caspases-3, -7, -8, -9, -10, and -12 and inhibiting apoptosis when used at 10 μM. It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK and Boc-D-FMK . Q-VD-OPH can be used in vivo, where it has been shown to prevent ischemia-reperfusion injury-induced apoptosis. This compound, by broadly inhibiting caspases, also promotes the differentiation of leukemic blasts cells, suggesting an application in differentiation therapy of certain forms of cancer.
Uses
Q-VD-OPh hydrate has been used:
- as a pan-caspase inhibitor to prevent cell death in urothelial carcinoma cells (UCC)
- to induce canonical caspase-dependent apoptosis in UC cells
- to block caspase-3 and Poly (ADP-ribose) polymerase-1 (PARP-1)
- to study the protective role of EspZ effector protein against apoptosis and necrosis in human epithelial cells
Uses
An inhibitor that is used in Alzheimer’s studies relating to caspase-6, the cysteinyl protease involved in neurodegenerative conditions. As well it is an intermediate in the formation of Palinavir, a potent HIV protease inhibitor.
Biochem/physiol Actions
Q-VD-OPh is a potent pan-caspase inhibitor that protects cells from capsase-dependent apoptosis. Q-VD-OPh has superior aqueous stability, cell permeability, and efficacy than FMK-based caspase inhibitors and displays no cytotoxic effects alone.
target
caspase-1
storage
+4°C
References
1) Caserta?et al.?(2003),?Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties; Apoptosis,?8?345 2) Braun?et al.?(2007),?Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH; Exp. Neurol.,?206?183 3) Rebbaa?et al.?(2003),?Caspase inhibition switches doxorubicin-induced apoptosis to senescence; Oncogene,?22?2805 4) Bulatovic?et al.?(2015),?Sublethal caspase activation promotes generation of cardiomyocytes from embryonic stem cells; PLoS One,?10?e0120176 5) Bailey?et al. (2017),?Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis;?Cell Death Dis.,?8?e2590
Q-VD-OPh hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Q-VD-OPh hydrate Suppliers
- Tel
- +1-832-696-8203
- Fax
- +1-832-641-3177
- info@apexbt.com
- Country
- United States
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- 477
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- 60
- Tel
- info@creative-peptides.com
- Country
- United States
- ProdList
- 6084
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- 56
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
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- 19892
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- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6393
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- 58
- Tel
- +1 (732)236-3202
- sales@cckinase.com
- Country
- United States
- ProdList
- 2738
- Advantage
- 58
- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57511
- Advantage
- 58
View Lastest Price from Q-VD-OPh hydrate manufacturers
- Product
- Q-VD-OPh hydrate 1135695-98-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 2tons
- Release date
- 2019-12-19